During each of eight study visits, 18 volunteer smoker subjects randomly used one of either their usual brand (UB) of cigarette, a BIDI ® Stick ENDS, or a comparator ENDS (JUUL 59 mg/ml nicotine with Virginia Tobacco flavour), during both controlled (10 puffs, 30 s apart) and ad libitum (60 min) puffing sessions. In this study, we assessed nicotine pharmacokinetics and subjective effects of 6 flavour variants of BIDI ® Stick ENDS in adult smokers, compared to cigarettes and a comparator ENDS product. The BIDI ® Stick is a disposable ENDS product which contains 59 mg/ml nicotine benzoate salt and various flavours. Subjective effects data also strongly contribute to this understanding.
Nicotine pharmacokinetic assessments of electronic nicotine delivery systems (ENDS) are crucial to understand their ability to provide an alternative to cigarette smoking.
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